Folks with power migraines who use hashish merchandise are more likely to endure from “rebound complications” than those that do not use the medicine, a preliminary examine suggests.
Nonetheless, although a hyperlink has been uncovered, it is nonetheless unclear whether or not hashish instantly triggers the rebound complications, the examine authors advised Reside Science. The examine additionally did not specify what forms of hashish merchandise the sufferers used, so it is unknown whether or not sure merchandise present a larger correlation to rebound complications than others.
A rebound headache, also referred to as a medication-overuse headache (MOH), occurs when an individual who already has a headache dysfunction, reminiscent of power migraine, both develops a brand new sort of headache or their current complications considerably worsen over time as a result of they’re taking headache treatment too often, in keeping with the Worldwide Classification of Headache Issues (ICHD 3).
A proper analysis of rebound complications implies that an individual has repeatedly overused a number of medicine to deal with their complications for greater than three months. That normally means taking pain-relieving or antimigraine drugs greater than two or three days per week, in keeping with Harvard Well being. As well as, a identified individual could have skilled complications on 15 or extra days every month. The rebound complications normally resolve if sufferers cease overusing the drugs.
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These complications have an effect on about 1% to three% of individuals within the common inhabitants and almost one-third of the sufferers who search therapy for complications at specialised clinics, such because the Stanford Headache Heart, examine writer Dr. Niushen Zhang, a scientific assistant professor and director of the Headache Fellowship Program at Stanford College Faculty of Medication, advised Reside Science in an electronic mail.
Now, of their new examine, Zhang and her colleagues discovered that individuals with power migraines seem six instances extra more likely to expertise rebound complications in the event that they use hashish, as in contrast with migraine sufferers who do not use the drug. The scientists will current the unpublished analysis on the American Academy of Neurology’s 73rd Annual Assembly, to be held nearly in April.
“This examine reveals that there’s some sort of affiliation between hashish use and medication-overuse headache in folks with power migraine,” Zhang mentioned.
Nonetheless, the analysis remains to be in its early days, and “it’s unclear right now whether or not sufferers are utilizing hashish to deal with medication-overuse headache or if hashish is contributing to the event [of] medication-overuse headache, or each,” Zhang mentioned. Future research shall be wanted to find out whether or not hashish contributes to the emergence of rebound complications, and in that case, what which means for these with power migraines, she mentioned.
For now, “it’s too early to offer any scientific suggestions based mostly on the present findings,” Zhang added.
Zhang and her colleagues launched their examine after noticing that a variety of their sufferers with each power migraines and MOH additionally used hashish merchandise, she mentioned. As there’s little or no analysis on hashish use and these headache issues, the group determined to discover the affiliation additional.
“Our examine is the primary of its variety to evaluate the chance of medication-overuse headache in power migraine sufferers who use hashish,” Zhang mentioned.
The group pulled information from the Stanford Analysis Repository Cohort Discovery Device, amassing data on power migraine sufferers handled between 2015 and 2019. They included 368 adults who had skilled power migraine for a minimum of a yr; 150 reported utilizing hashish merchandise, and 218 didn’t use any.
The group then assessed which sufferers had been identified with MOH, taking different variables into consideration, reminiscent of how typically they received migraines, how lengthy they’d been utilizing hashish, after they received identified with MOH and what different drugs they took for complications.
They discovered that 212 sufferers had MOH, and that sufferers who reported hashish use have been much more more likely to be identified with the dysfunction. There was additionally a big hyperlink between hashish use, opioid use and rebound complications, they discovered. “A number of the sufferers within the examine who have been utilizing hashish have been additionally taking, or had a historical past of taking, opioids,” Zhang mentioned.
Once more, future research might want to examine if and the way these medicine increase the chance of rebound complications, in addition to what occurs when folks take them concurrently.
The cannabinoids in hashish merchandise bind to receptors within the physique that regulate the notion of ache, and there’s proof that hashish merchandise may help alleviate sure forms of power ache, Reside Science beforehand reported. That mentioned, since this new examine reveals a possible hyperlink between the medicine and rebound complications, extra analysis shall be wanted to see whether or not hashish units migraine sufferers up for worse complications, Zhang mentioned.
Once more, for now, it is too early to say for positive.
Initially printed on Reside Science.